As an amateur, Matty Askin boxed for the Pool of Life Amateur Boxing Club and was crowned the 2008 Senior ABA champion at cruiserweight.
He turned professional shortly after, in November 2008, after signing with VIP promoter Steve Wood and defeated Paul Bonson at The Tower Ballroom in Blackpool on his debut.
In January 2009, he signed with promoter Ricky Hatton, who took his record to 11 wins without defeat.
During 2011, Sky Sports shortlisted Askin as a top prospect to watch in 2011. In March that year he won his first title as a professional by knocking out Neil Dawson in six rounds in Wigan to become the Central Area Cruiserweight champion.
In November 2012, Askin suffered his first defeat by KO to current WBO world cruiserweight champion Krzysztof Glowacki.
On 26 May 2017, Askin stopped Craig Kennedy in the sixth round to become British cruiserweight champion.